Google Scholar Profile https://scholar.google.de/citations?user=iq6-xm4AAAAJ&hl=de&oi=ao

* equal contribution
# correspondence

2025

[36]        Huber, E. M.*, Heinemeyer, W.*, Groll, M. (2025)  
                Proteasome-associated autoinflammatory syndromes: The impact of mutations in proteasome subunits on particle assembly,                         structure, and activity
                Structure, 33(12), 2084-2094.e5
                Featured on the cover

[35]        Wirawan, R., Frei, M., Heider, A., Papenkordt, N., Friedrich, F., Wein, T., Jung, M., Groll, M., Huber, E. M., Bracher, F. (2025)  
                Tailored SirReal-type inhibitors enhance SIRT2 inhibition through ligand stabilization and disruption of NAD+ co-factor binding
                RCS Med. Chem., 16(11), 5419-5440

2024

[34]        Su, L.*, Huber, E. M.*, Westphalen, M., Gellner, J., Bode, E., Köbel, T., Grün, P., Alanjary, M. M., Glatter, T., Cirnski, K., Müller, R.,                             Schindler, D., Groll, M., Bode, H. B. (2024)  
                Isofunctional but Structurally Different Methyltransferases for Dithiolopyrrolone Diversification
                Angew. Chem. Int. Ed., 63(49), e202410799

2023

[33]        Huber, E. M.*,#, Kreling, L.*, Heinrich, A. K., Dünnebacke, M., Pöthig, A., Bode, H. B.#, Groll, M.# (2023)
                A set of closely related methyltransferases for site-specific tailoring of anthraquinone pigments
                Structure, 31(5), 573-583.e5
                Featured on the cover

2022

[32]        Huber, E. M.# (2022)
                Epipolythiodioxopiperazine-based natural products: building blocks, biosynthesis and biological activities
                ChemBioChem, 23, e202200341, invited for ChemBioTalents

[31]        Huber, E. M.*, Hortschansky, P.*, Scheven, M. T., Misslinger, M., Haas, H., Brakhage, A. A., Groll, M. (2022)
                Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX
                Structure, 30(7), 934-946
                 Featured on the cover

2021

[30]        Huber, E. M. # and Groll, M.# (2021)
                A Nut for Every Bolt: Subunit-Selective Inhibitors of the Immunoproteasome and Their Therapeutic Potential
                Cells, 10(8), 1929, 1-22

[29]        Scherlach, K., Kuttenlochner, W., Scharf, D. H., Brakhage, A. A., Hertweck, C., Groll, M., Huber, E. M.# (2021)
                Structural and mechanistic insights into C-S bond formation in gliotoxin
                Angew. Chem. Int. Ed., 60(25), 14188-14194

2020

[28]         Hortschansky, P., Misslinger, M., Mörl, Y., Gsaller, F., Bromley, M. J., Brakhage, A. A., Groll, M., Haas, H., Huber, E. M.# (2020)
                 Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus
                 Life Sci. Alliance, 3(7), e202000729

2019

[27]         Schmidtke, G., Schregle, R., Alvarez, G., Huber, E. M., Groettrup, M. (2019)
                 The 20S immunoproteasome and constitutive proteasome bind with the same affinity to PA28αβ and equally degrade FAT10
                 Mol. Immunol., 113, 22-30 

[26]         Schopf, F. H., Huber, E. M., Dodt, C., Lopez, A., Biebl, M. M., Rutz, D. A., Mühlhofer, M., Richter, G., Madl, T., Sattler, M., Groll, M.,                          Buchner, J. (2019)
                 The co-chaperone Cns1 and the recruiter protein Hgh1 link Hsp90 to translation elongation via chaperoning elongation factor 2
                 Mol. Cell, 74(1), 73-87

[25]         Xin, B.-T.*, Huber, E. M.*, de Bruin, G., Heinemeyer, W., Maurits, E., Espinal, C., Du, Y., Jansen, M., Weyburne, E. S., Kisselev, A. F.,                        Florea, B. I., Driessen, C., van der Marel, G. A., Groll, M. and Overkleeft, H. S. (2019)
                 Structure-based design of inhibitors selective for human proteasome β2c or β2i subunits
                 J. Med. Chem., 62(3), 1626-42

2018

[24]         Ecker, F. #, Haas, H., Groll, M., Huber, E. M.# (2018)
                 Iron scavenging in Aspergillus species: Structural and biochemical insights into fungal siderophore esterases 
                 Angew. Chem. Int. Ed., 57(44), 14624-9

[23]         Treise, I.*, Huber, E. M.*, Klein-Rodewald, T., Heinemeyer, W., Grassmann, S. A., Basler, M., Adler, T., Rathkolb, B., Helming, L., And                  res, C., Klaften, M., Landbrecht, C., Wieland, T., Strom, T. M., McCoy, K. D., Macpherson, A. J., Wolf, E., Groettrup, M., Ollert, M., Neff,                  F., Gailus-Durner, V., Fuchs, H., Hrabě de Angelis, M., Groll, M., Busch, D. H. (2018)
                 Defective immuno- and thymoproteasome assembly causes severe immunodeficiency
                  Scientific Reports, 8(1), 5975

2017

[22]         Huber, E. M. # and Groll, M.# (2017)
                 The mammalian proteasome activator PA28 forms an asymmetric α4β3 complex
                 Structure, 25(10), 1473-1480

[21]         Marion, A., Groll, M., Scharf, D. H., Scherlach, K., Glaser, M., Sievers, H., Schuster, M., Hertweck, C., Brakhage, A. A., Antes, I., # Hu-                    ber, E. M. # (2017)
                 Gliotoxin biosynthesis: Structure, mechanism and metal promiscuity of carboxypeptidase GliJ
                 ACS Chem. Biol., 12(7), 1874-1882

[20]         Cui, H., Baur, R., Le Chapelain, C., Dubiella, C., Heinemeyer, W., Huber, E. M., Groll, M. (2017)
                 Structural elucidation of a non-peptidic inhibitor specific for the human immunoproteasome 
                  ChemBioChem., 18(6), 523-6

[19]         Hortschansky, P., Haas, H., Huber, E. M., Groll, M., Brakhage, A. A. (2017)
                 The CCAAT-binding complex (CBC) in Aspergillus species
                 Biochim. Biophys. Acta., 1860(5), 560-70

2016

[18]         Huber, E. M.*, Heinemeyer, W.*, de Bruin, G., Overkleeft, H. S., Groll, M. (2016)
                 A humanized yeast proteasome identifies unique binding modes of inhibitors for the immunosubunit β5i
                  EMBO J., 35(23), 2602-13
                Featured on the cover

[17]         Xin, B.-T., de Bruin, G., Huber, E. M., Andrej, B., Florea, B. I., Filippov, D. V., van der Marel, G. A., Kisselev, A. F., van der Stelt, M.,                          Driessen, C., Groll, M., Overkleeft, H.S. (2016)
                 Structure-based design of β5c selective inhibitors of human constitutive proteasomes 
                 J. Med. Chem., 59(15), 7177-87

[16]        Huber, E. M.#, Heinemeyer, W., Li, X., Arendt, C. S.,  Hochstrasser, M., Groll, M.# (2016)
                A unified mechanism for proteolysis and autocatalytic activation in the 20S proteasome 
                 Nat. Commun., 7, 10900, 1-10

[15]         Duell, E. R., Glaser, M., Le Chapelain, C., Antes, I., Groll, M., Huber, E. M.# (2016)
                 Sequential inactivation of gliotoxin by the S-methyltransferase TmtA 
                  ACS Chem. Biol., 11(4), 1082–9

2015

[14]         Dubiella, C., Baur, R., Cui, H., Huber, E. M., Groll, M. (2015)
                 Selective inhibition of the immunoproteasome by structure-based targeting of a non-catalytic cysteine
                 Angew. Chem. Int. Ed., 54(52), 15888-9

[13]         Huber, E. M.*, de Bruin, G.*, Heinemeyer, W., Paniagua Soriano, G., Overkleeft, H. S., Groll M. (2015)
                 Systematic analyses of substrate preferences of 20S proteasomes using peptidic epoxyketone inhibitors
                 J. Am. Chem. Soc., 137(24), 7835-42

[12]         Groll, M., Korotkov, V. S., Huber, E. M., de Meijere, A., Ludwig, A. (2015)
                 A minimal β-lactone fragment for selective β5c or β5i proteasome inhibitors
                 Angew. Chem. Int. Ed., 54(27), 7810-4

[11]         Huber, E. M.#, Heinemeyer, W., Groll, M.# (2015)
                 Bortezomib-resistant mutant proteasomes: structural and biochemical evaluation with carfilzomib and ONX 0914
                 Structure, 23(2), 407–17

2014

[10]         de Bruin, G.*, Huber, E. M.*, Xin, B.-T., van Rooden, E. J., Al-Ayed, K., Kim, K.-B., Kisselev, A. F., Driessen, C., van der Stelt, M., van                        der  Marel, G. A., Groll, M., Overkleeft, H. S. (2014) 
                 Structure-based design of β1i or β5i specific inhibitors of human immunoproteasomes
                  J. Med. Chem., 57(14), 6197−209

[9]           Scharf, D. H., Groll, M., Habel, A., Heinekamp, T., Hertweck, C., Brakhage, A. A., Huber, E. M.# (2014) 
                 Flavoenzyme-catalyzed disulfide bridge formation in natural products
                 Angew. Chem. Int. Ed., 53(8), 2221–4

2013

[8]           Huber, E. M., Groll, M. (2013)
                Proteasominhibitoren – von der Grundlagenforschung in die Klinik
                 BIOspektrum, 7, 730-2

[7]           Huber, E. M. (2013)
                Structural and functional characterization of the immunoproteasome
                 Springer Theses, Recognizing Outstanding Ph.D. Research, ISBN: 978-3-319-01555

2012

[6]           Huber, E. M.*, Scharf, D. H.*, Hortschansky, P., Groll, M., Brakhage, A. A. (2012)
                DNA minor groove sensing and widening by the CCAAT-binding complex
                 Structure, 20(10), 1757-68

[5]           Huber, E. M.# and Groll, M.# (2012)
                 Inhibitors for the immuno- and constitutive proteasome: current and future trends in drug development
                 Angew. Chem. Int. Ed., 51(35), 8708-20

[4]           Huber, E. M. and Groll, M. (2012)
                 Kristallstruktur eines molekularen Schredders
                 GIT Labor-Fachzeitschrift, 5, 363-5

[3]           Huber, E. M. and Groll, M. (2012)
                 The 19S cap puzzle: A new jigsaw piece
                 Structure, 20(3), 387-8

[2]           Huber, E. M.*, Basler, M.*, Schwab, R.*, Heinemeyer, W., Kirk, C. J., Groettrup, M., Groll, M. (2012)
                 Immuno- and constitutive proteasome crystal structures reveal differences in substrate and inhibitor specificity
                  Cell, 148(4), 727-38
                  Recommended by Faculty of 1000

2010

[1]           Wünschmann, J., Krajewski, M., Letzel, T., Huber, E. M., Ehrmann, A., Grill, E., Lendzian, K. J. (2010)
                 Dissection of glutathione conjugate turnover in yeast
                 Phytochemistry, 71(1), 54-61